nevirapine will lower the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.lorlatinib will lower the level or impact of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Steer clear of usage of lorlatinib with CYP3A substrates, exactly wh